| Cat.No.: | PE-1289 |
| Product Name: | Recombinant Human ASF1A, His-tagged |
| Product Overview: | Recombinant human ASF1A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. MW = 27 kDa (240aa). |
| Description: | ASF1 anti-silencing function 1 homolog A, also known as ASF1A, belongs to H3/H4 family of histone chaperone proteins. ASF1A protein interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. Deletion of ASF1A in yeast and Drosophila confers sensitivity to various DNA damaging agents and inhibitors of DNA replication, increases genomic instability and sister chromatid exchange, and activates the DNA damage checkpoint. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | > 90% by SDS – PAGE. |
| Species: | Human |
| Formulation: | Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol. |
| Tag: | His |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAKV QVNNVVVLDN PSPFYNPFQF EITFECIEDL SEDLEWKIIY VGSAESEEYDQVLDSVLVGP VPAGRHMFVF QADAPNPGLI PDADAVGVTV VLITCTYRGQ EFIRVGYYVN NEYTETELRE NPPVKPDFSK LQRNILASNP RVTRFHINWE DNTEKLEDAE SSNPNLQSLL STDALPSASK GWSTSENSLN VMLESHMDCM. |
| Endotoxin: | < 1.0 EU per 1 μg of protein (determined by LAL method ). |
| Expression System: | E. coli |
| Concentrations: | 1 mg/ml (determined by Bradford assay). |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae) [ Homo sapiens ] |
| Gene ID NCBI: | 25842 |
| Synonyms: | ASF1A; ASF1 anti-silencing function 1 homolog A (S. cerevisiae); CIA; CGI-98; HSPC146; DKFZp547E2110; ASF1 anti-silencing function 1 homolog A; CCG1-interacting factor A; anti-silencing function 1A; DKFZP547E2110; DKFZp547E2110 |
| mRNA Refseq: | NM_014034 |
| Protein Refseq: | NP_054753 |
| MIM: | 609189 |
| UniProt ID: | Q9Y294 |
| Chromosome Location: | 6q22.31 |
| Function: | chromatin binding; histone binding |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0018 | Human ASH1L Knockout Cell Line 53bp deletion | Inquiry |
| CL-0019 | Human ASXL2 Knockout Cell Line 1bp insertion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0162 | Recombinant Human ASH2L 293 Cell Lysate | Inquiry |
| EL-0173 | Recombinant Human ASF1A 293 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0168 | ASH2 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| ASB10 | ASB11 | ASB13 | ASB6 |
| ASB7 | ASB8 | ASB9 | ASF1 |
| ASH1L | ASH2 | ASXL2 | |
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