| Cat.No.: | PE-1278 |
| Product Name: | Recombinant Human CTSL1, His-tagged |
| Product Overview: | Recombinant full length protein with 6XHis-tag on its N-terminus |
| Description: | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | >90% by SDS-PAGE |
| Species: | Human |
| Formulation: | Lyophilised:With dH2O to 0.1 – 1 mg/ml |
| Tag: | His |
| Sequence Similarities: | Belongs to the peptidase C1 family. |
| Activity: | Specific Activity: 6000 units/mg protein. One unit will hydrolyze one nmol Z-Phe-Arg-AFC substrate per minute at 37℃ in 400 mM Sodium Acetate, pH 5.5, with 4 mM EDTA and 10 mM DTT. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | CTSL1 cathepsin L1 [ Homo sapiens ] |
| Gene ID NCBI: | 1514 |
| Official Symbol: | CTSL1 |
| Synonyms: | CTSL1; cathepsin L1; cathepsin L , CTSL; FLJ31037; |
| mRNA Refseq: | NM_001912 |
| Protein Refseq: | NP_001903 |
| MIM: | 116880 |
| UniProt ID: | P07711 |
| Chromosome Location: | 9q21.33 |
| Function: | cysteine-type endopeptidase activity; histone binding; peptidase activity; protein binding; |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0168 | Human CTDSP1 Knockout Cell Line 26bp deletion | Inquiry |
| CL-0195 | Human CTDSPL Knockout Cell Line 1bp insertion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0169 | Recombinant Human CTSL1 Cell Lysate | Inquiry |
| EL-0204 | Recombinant Human CTCFL 293 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0849 | CTCF Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| CTBP | CTBP2 | CTCF | CTCFL |
| CTDSP1 | CTDSPL | CtIP | ctnnb1 |
| CTSL1 | |||
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