| Cat.No.: | PE-1182 |
| Product Name: | Recombinant Human TET2, GST-tagged |
| Product Overview: | Recombinant human TET2 (1197-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine which is involved in myelopoiesis. Defects in TET2 gene have been associated with several myeloproliferative disorders. TET2 play an important role in embryonic stem cell maintenance and inner cell mass cell specification. TET proteins have potential roles in epigenetic regulation through modification of 5mC to 5hmC. TET2 enzymatic activity is involved in myeloid tumorigenesis and this could be valuable as a diagnostic and prognostic tool for targeted therapies and to assess responses to anticancer drugs. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | ~124 kDa |
| Purity: | >70% by densitometry |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Concentrations: | 0.1 μg/μl |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | TET2 tet methylcytosine dioxygenase 2 [ Homo sapiens ] |
| Gene ID NCBI: | 54790 |
| Synonyms: | TET2; tet methylcytosine dioxygenase 2; KIAA1546 , tet oncogene family member 2; methylcytosine dioxygenase TET2; FLJ20032; tet oncogene family member 2; probable methylcytosine dioxygenase TET2; MDS; KIAA1546; MGC125715; |
| mRNA Refseq: | NM_001127208 |
| Protein Refseq: | NP_001120680 |
| MIM: | 612839 |
| UniProt ID: | Q6N021 |
| Chromosome Location: | 4q24 |
| Function: | metal ion binding; methylcytosine dioxygenase activity; methylcytosine dioxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0154 | Recombinant Human TET3 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0176 | TEAD2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0215 | Human TET1 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0217 | Human TET2 Knockout Cell Line 19bp deletion | Inquiry |
| CL-0218 | Human TET3 Knockout Cell Line 14bp deletion | Inquiry |
| Related Gene / Proteins | |||
| TEAD1 | TEAD2 | telomerase | TEN1 |
| TENR | TERF2IP | TET | TET1 |
| TET2 | TET3 | ||
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