| Cat.No.: | PE-1092 |
| Product Name: | Recombinant Human SET Domain Containing (lysine methyltransferase) 7, GST-tagged |
| Product Overview: | Recombinant full-length human SETD7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | SETD7 is a lysine methyltransferase which can methylates lysine-4 in histone H3 in vitro and in vivo. Methylation of K4 in histone H3 by SETD7 and methylation of K9 in histone H3 by SUV39H1 were found to have differential effects on subsequent histone acetylation by p300. SETD7 can also methylate p53 at lys372 within the C-terminal regulatory region. Methylated p53 is restricted to the nucleus and the modification positively affects its stability. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 74 kDa |
| Purity: | > 95 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol. |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Full length |
| Concentrations: | 0.1 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SETD7 SET domain containing (lysine methyltransferase) 7 [ Homo sapiens ] |
| Gene ID NCBI: | 80854 |
| Official Symbol: | SETD7 |
| Synonyms: | SETD7; SET domain containing (lysine methyltransferase) 7; KMT7; SET7; SET9; SET7/9; FLJ21193; KIAA1717; histone-lysine N-methyltransferase SETD7; H3-K4-HMTase SETD7; OTTHUMP00000164543; OTTHUMP00000220049; lysine N-methyltransferase 7; SET domain-containing protein 7; histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; EC 2.1.1.43; Histone-lysine N-methyltransferase SETD7; Histone H3-K4 methyltransferase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7 |
| mRNA Refseq: | NM_030648 |
| Protein Refseq: | NP_085151 |
| MIM: | 606594 |
| UniProt ID: | Q8WTS6 |
| Chromosome Location: | 4q31.1 |
| Function: | histone-lysine N-methyltransferase activity; methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity; transferase activity |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| SENP3 | SENP8 | SET | SET1 |
| SET2 | SET7 | SET8 | SET9 |
| SETBP1 | SETD1A | SETD1B | SETD2 |
| SETD3 | SETD5 | SETD6 | SETD7 |
| SETD8 | SETD9 | SetDB1 | SETDB2 More > |
| SETMAR | |||
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