| Cat.No.: | PE-1056 |
| Product Name: | Recombinant Human Protein Arginine Methyltransferase 1, GST-tagged |
| Product Overview: | Recombinant full-length human PRMT1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | PRMT1 is a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4. PRMT1 specifically methylates arginine-3 of histone H4 in vitro and in vivo. Methylation of arg3 by PRMT1 facilitates subsequent acetylation of histone H4 tails by p300. PRMT1 performs methylation of arg31 of STAT1 and this is required for transcription induced by IFN-alpha/IFN-beta. Arginine methylation of STAT1 is an additional posttranslational modification regulating transcription factor function, and alteration of arginine methylation might be responsible for the lack of interferon responsiveness observed in many malignancies. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 67 kDa |
| Purity: | > 90 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM Tris-HCL, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol, 0.1 mM EDTA. |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Concentrations: | 0.1 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | PRMT1 protein arginine methyltransferase 1 [ Homo sapiens ] |
| Gene ID NCBI: | 3276 |
| Synonyms: | PRMT1; protein arginine methyltransferase 1; ANM1; HCP1; IR1B4; HRMT1L2;protein arginine N-methyltransferase 1; OTTHUMP00000236172; OTTHUMP00000236176; OTTHUMP00000236178; OTTHUMP00000236179; HMT1 hnRNP methyltransferase-like 2; interferon receptor 1-bound protein 4; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; NP_938074.2; EC 2.1.1.125 |
| mRNA Refseq: | NM_198318 |
| Protein Refseq: | NP_938074 |
| MIM: | 602950 |
| UniProt ID: | Q8WUW5 |
| Chromosome Location: | 19q13.3 |
| Function: | N-methyltransferase activity; core promoter proximal region DNA binding; enzyme binding; histone methyltransferase activity; histone methyltransferase activity (H4-R3 specific); methyltransferase activity; protein binding; transferase activity |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| BSM-0047 | SGC707 | Inquiry |
| ◆ Antibodies | ||
| EAb-0048 | PRMT6 Polyclonal Antibody | Inquiry |
| EAb-0049 | PRMT7 Polyclonal Antibody | Inquiry |
| EAb-0050 | PRMT1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Pr-SET7 | PRC1 | PRC2 | PRDM1 |
| PRDM10 | PRDM11 | PRDM12 | PRDM13 |
| PRDM14 | PRDM15 | PRDM16 | PRDM17 |
| PRDM2 | PRDM3 | PRDM4 | PRDM5 |
| PRDM6 | PRDM7 | PRDM8 | PRDM9 More > |
| PREP1 | PRIM2 | PRKAA2 | PRKCA |
| PRKCB | PRKCE | PRKDC | PRKRIP1 |
| PRMT | prmt1 | PRMT2 | PRMT3 |
| PRMT5 | prmt6 | PRMT7 | PRMT8 |
| PRMT9 | Progerin | Protamine 2 | Prox1 |
| PRPF31 | PRPF40A | PRSS12 | PRSS55 |
| PRTFDC1 | |||
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