| Cat.No.: | PE-1031 |
| Product Name: | Recombinant Human SUV39H1, GST-tagged |
| Product Overview: | Recombinant full-length human SUV39H1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | SUV39H1 is a histone H3-specific methyltransferases that selectively methylates lysine-9 of the N terminus of histone H3 in vitro. SUV39H1 is also a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. SUV39H1 moves to the centromeres during mitosis where it functions as a histone methyltransferase, methylating Lys-9 of histone H3. SUV39H1 activity is regulated by acetylation at lysine residue 266 in its catalytic SET domain by SIRT1. SIRT1 interacts directly with, recruits, and deacetylates SUV39H1, and these activities independently contribute to elevated levels of SUV39H1 activity resulting in increased levels of the H3K9me3 modification. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | ~73 kDa |
| Purity: | >70% |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Full length |
| Concentrations: | 0.1 μg/μ |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) [ Homo sapiens ] |
| Gene ID NCBI: | 6839 |
| Synonyms: | SUV39H1; suppressor of variegation 3-9 homolog 1 (Drosophila); suppressor of variegation 3 9 (Drosophila) homolog 1 , SUV39H; histone-lysine N-methyltransferase SUV39H1; KMT1A; H3-K9-HMTase 1; Su(var)3-9 homolog 1; lysine N-methyltransferase 1A; histone H3-K9 methyltransferase 1; position-effect variegation 3-9 homolog; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; MG44; SUV39H; |
| mRNA Refseq: | NM_003173 |
| Protein Refseq: | NP_003164 |
| MIM: | 300254 |
| UniProt ID: | O43463 |
| Chromosome Location: | Xp11.23 |
| Function: | S-adenosylmethionine-dependent methyltransferase activity; chromatin binding; histone methyltransferase activity; histone methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; protein N-terminus binding; protein binding; transferase activity; zinc ion binding; |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0020 | Suz12 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0100 | Chaetocin | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0103 | Recombinant Human SUZ12 293 Cell Lysate | Inquiry |
| EL-0132 | Recombinant Human SUV39H1 293 Cell Lysate | Inquiry |
| EL-0137 | Recombinant Human SUV420H1 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| SUDS3 | SUMO | SUMO1 | SUMO2 |
| SUMO3 | SUN1 | Surf6 | suv39h1 |
| SUV39H2 | SUV3L1 | SUV420H1 | SUV420H2 |
| SUZ12 | |||
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