| Cat.No.: | PE-0993 |
| Product Name: | Recombinant Human Euchromatic Histone-lysine N-methyltransferase 1 |
| Product Overview: | Glucagon Like Peptide-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 30 amino acids and having a molecular mass of 3298.7 Dalton. The GLP-1 is purified by proprietary chromatographic techniques. |
| Description: | Glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a guthormone. The biologically active forms of GLP-1 are: GLP-1-(7-37) and GLP-1-(7-36)NH2. GLP-1 secretion by L cells is dependent on the presence of nutrients in the lumen of the small intestine. The secretagogues (agents that causes or stimulates secretion) of this hormone include major nutrients like carbohydrate, proteinand lipid. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Purity: | Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Species: | Human |
| Formulation: | The Recombinant GLP-1 concentrated solution (1 mg/ml) was lyophilized after extensive dialyses against 0.1 mg sodium phosphate monobasic & 1.6 mg sodium phosphate dibasic. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be His-Ala-Glu-Gly-Thr. |
| Reconstitution: | It is recommended to reconstitute the lyophilized Glucagon Like Peptide-1 in sterile 18Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Activity: | 1. Regulates Glucose levels rapidly 2. Reduces Insulin resistence 3. Reduces Glucagon 4. Reduces HbA1c 5. Stimulates beta cell growth which stimulates insulin production. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | EHMT1 euchromatic histone-lysine N-methyltransferase 1 [ Homo sapiens ] |
| Gene ID NCBI: | 79813 |
| Official Symbol: | EHMT1 |
| Synonyms: | EHMT1; euchromatic histone-lysine N-methyltransferase 1; GLP; GLP1; KMT1D; FP13812; FLJ12879; KIAA1876; EUHMTASE1; Eu-HMTase1; bA188C12.1; DKFZp667M072; RP11-188C12.1; histone-lysine N-methyltransferase EHMT1; H3-K9-HMTase 5; G9a like protein; G9a-like protein 1; OTTHUMP00000022711; OTTHUMP00000022713; OTTHUMP00000212228; lysine N-methyltransferase 1D; histone H3-K9 methyltransferase 5; histone-lysine N-methyltransferase, H3 lysine-9 specific 5; NP_001138999.1; EC 2.1.1.43; NP_079033.4 |
| mRNA Refseq: | NM_001145527 |
| Protein Refseq: | NP_001138999 |
| MIM: | 607001 |
| UniProt ID: | Q9H9B1 |
| Chromosome Location: | 9q34.3 |
| Function: | histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; p53 binding; protein-lysine N-methyltransferase activity; transferase activity; zinc ion binding |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0025 | BIX01294 (hydrochloride hydrate) | Inquiry |
| BSM-0026 | UNC0224 | Inquiry |
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Cell Lines | ||
| CL-0059 | Human EHMT1 Knockout Cell Line 7bp deletion | Inquiry |
| CL-0060 | Human EHMT2 Knockout Cell Line 34bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EHD2 | EHMT1 | EHMT2 | |
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