| Cat.No.: | PE-0970 |
| Product Name: | Recombinant Human BRCA2 protein, His & T7-tagged |
| Product Overview: | Recombinant Human BRCA2 aa. (Lys2308~His2537 (Accession # P51587)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
| Description: | Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. |
| Applications: | SDS-PAGE; WB; ELISA; IP. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Freeze-dried powder |
| Molecular Weight: | Predicted Molecular Mass: 30.0kDa. |
| Purity: | >95% |
| Species: | Human |
| Tag: | His & T7 |
| Endotoxin: | <1.0EU per 1ug (determined by the LAL method) |
| Reconstitution: | Reconstitute in ddH2O. |
| Expression System: | E. coli |
| Isoelectric Point: | The isoelectric point is 9.7. |
| Protein Length: | Lys2308~His2537 (Accession # P51587) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | BRCA2 BRCA2, DNA repair associated [ Homo sapiens (human) ] |
| Gene ID NCBI: | 675 |
| Official Symbol: | BRCA2 |
| Synonyms: | FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2; BRCA1/BRCA2-containing complex, subunit 2; Fanconi anemia group D1 protein; breast and ovarian cancer susceptibility gene, early onset; breast and ovarian cancer susceptibility protein 2; breast cancer 2 tumor suppressor; breast cancer 2, early onset; mutant BRCA2; truncated breast cancer 2; breast cancer type 2 susceptibility protein |
| mRNA Refseq: | NM_000059.3 |
| Protein Refseq: | NP_000050.2 |
| UniProt ID: | P51587 |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0006 | Bromodomain Ligand 4 | Inquiry |
| Related Gene / Proteins | |||
| BRCA1 | BRCA2 | BRCC3 | BRD |
| brd1 | brd2 | brd3 | brd4 |
| BRD7 | BRD8 | brd9 | brdt |
| BRL | BRM | BRMS1 | BRPF1 |
| BRPF2 | brpf3 | BRWD1 | BRWD3 |
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