| Cat.No.: | PE-0767 |
| Product Name: | Recombinant Human XBP1 Protein, GST-HIS-tagged |
| Product Overview: | Recombinant Human XBP1, transcript variant 1, fused with N-terminall GST and C-terminall His was expressed in E. coli. |
| Description: | This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 54.5 kDa |
| Purity: | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Species: | Human |
| Formulation: | 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl. |
| Tag: | GST-His |
| Expression System: | E. coli |
| Concentrations: | >50 ug/mL as determined by microplate BCA method |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | XBP1 X-box binding protein 1 [ Homo sapiens ] |
| Gene ID NCBI: | 7494 |
| Official Symbol: | XBP1 |
| Synonyms: | XBP1; X-box binding protein 1; XBP2; X-box-binding protein 1; tax-responsive element-binding protein 5; TREB5; XBP-1; |
| mRNA Refseq: | NM_001079539 |
| Protein Refseq: | NP_001073007 |
| MIM: | 194355 |
| UniProt ID: | P17861 |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0095 | Recombinant Human XBP1 293 Cell Lysate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0272 | XBP1 Nuclear Translocation Assay Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0759 | Recombinant Human X-Box Binding Protein 1, His-tagged | Inquiry |
| PE-0760 | Recombinant Human X-Box Binding Protein 1, T7-tagged | Inquiry |
| PE-0761 | Recombinant Human XBP1, T7 -tagged | Inquiry |
| Related Gene / Proteins | |||
| xbp1 | |||
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