| Cat.No.: | PE-0702 |
| Product Name: | Recombinant Human Protein Kinase N2, GST-tagged, Active |
| Product Overview: | Recombinant full-length human PKN2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. MW=145kDa. |
| Description: | PKN2 (also known as PRK2) is a Rho effector and a member of the protein kinase C superfamily of serine/threonine kinases. PKN2 is an essential regulator of both entry into mitosis and exit from cytokinesis in HeLa S3 cells. PKN2 is required for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of Cdc25B, the phosphatase required for activation of mitotic cyclin/Cdk1 complexes at the G2/M transition. C-terminus of PKN2 could be a potential drug target for effector-specific pharmacological intervention of Rho-medicated biological processes. |
| Applications: | Kinase Assay, Western Blot. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Species: | Human |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Full-length. |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | PKN2 protein kinase N2 [ Homo sapiens ] |
| Gene ID NCBI: | 5586 |
| Synonyms: | PKN2; protein kinase N2; PAK2; PRK2; Pak-2; PRKCL2; PRO2042; MGC71074; MGC150606; protein kinase C-like 2; cardiolipin-activated protein kinase Pak2; EC 2.7.11.13 |
| mRNA Refseq: | NM_006256 |
| Protein Refseq: | NP_006247 |
| MIM: | 602549 |
| UniProt ID: | Q16513 |
| Chromosome Location: | 1p22.2 |
| Function: | ATP binding; nucleotide binding; protein kinase C activity; transferase activity |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0054 | PKC Polyclonal Antibody | Inquiry |
| EAb-0183 | PKM Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0078 | Recombinant Human PKN1 Cell Lysate | Inquiry |
| EL-0086 | Recombinant Human PKN2 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0203 | Ro 31-8220 methanesulfonate | Inquiry |
| Related Gene / Proteins | |||
| PKC | PKM | PKM2 | PKN1 |
| PKN2 | |||
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