| Cat.No.: | PE-0663 |
| Product Name: | Recombinant Human PKN1 protein, His & T7-tagged |
| Product Overview: | Recombinant Human PKN1 aa. (Phe615~Phe874 (Accession # Q16512)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
| Description: | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Applications: | SDS-PAGE; WB; ELISA; IP |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Freeze-dried powder |
| Molecular Weight: | Predicted Molecular Mass: 32.9kDa |
| Purity: | >95% |
| Species: | Human |
| Tag: | His & T7 |
| Endotoxin: | <1.0EU per 1µg (determined by the LAL method) |
| Reconstitution: | Reconstitute in sterile PBS, pH7.2-pH7.4. |
| Expression System: | E. coli |
| Isoelectric Point: | The isoelectric point is 5.9. |
| Protein Length: | Phe615~Phe874 (Accession # Q16512) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | PKN1 protein kinase N1 [ Homo sapiens (human) ] |
| Gene ID NCBI: | 5585 |
| Official Symbol: | PKN1 |
| Synonyms: | DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA; protease-activated kinase 1; protein kinase C-like 1; protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase PKN-alpha; serine-threonine kinase N; serine/threonine protein kinase N; serine/threonine-protein kinase N1 |
| mRNA Refseq: | NM_002741.3 |
| Protein Refseq: | NP_002732.3 |
| UniProt ID: | Q16512 |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0054 | PKC Polyclonal Antibody | Inquiry |
| EAb-0183 | PKM Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0078 | Recombinant Human PKN1 Cell Lysate | Inquiry |
| EL-0086 | Recombinant Human PKN2 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0203 | Ro 31-8220 methanesulfonate | Inquiry |
| Related Gene / Proteins | |||
| PKC | PKM | PKM2 | PKN1 |
| PKN2 | |||
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