| Cat.No.: | PE-0536 |
| Product Name: | Recombinant Human HES1, His-tagged |
| Product Overview: | Human HES1 (aa 2-280) is fused at the N-terminus to a His-tag. |
| Description: | bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | ~35kDa (SDS-PAGE) |
| Purity: | ≥90% (SDS-PAGE) |
| Species: | Human |
| Formulation: | Liquid. 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. |
| Tag: | His |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HES1 hairy and enhancer of split 1, (Drosophila) [ Homo sapiens ] |
| Gene ID NCBI: | 3280 |
| Synonyms: | HES1; hairy and enhancer of split 1, (Drosophila); hairy homolog (Drosophila) , HRY; transcription factor HES-1; bHLHb39; FLJ20408; HES 1; Hes1; hairy homolog; hairy-like protein; class B basic helix-loop-helix protein 39; HHL; HRY; HES-1; |
| mRNA Refseq: | NM_005524 |
| Protein Refseq: | NP_005515 |
| MIM: | 139605 |
| UniProt ID: | Q14469 |
| Chromosome Location: | 3q28-q29 |
| Function: | DNA binding; N-box binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; histone deacetylase binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding RNA polymerase II transcription factor activity; sequence-specific DNA binding transcription factor activity; transcription factor binding; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0061 | Recombinant Human HES1 293 Cell Lysate | Inquiry |
| EL-0112 | Recombinant Human HEY2 293 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0078 | Human HELLS Knockout Cell Line 1bp insertion | Inquiry |
| ◆ Antibodies | ||
| EAb-0363 | HELLS Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0534 | Recombinant Human HES1 | Inquiry |
| Related Gene / Proteins | |||
| HELLS | HELZ | HEMK1 | HERC3 |
| HERC6 | HES1 | HEY2 | |
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