| Cat.No.: | PE-0529 |
| Product Name: | Recombinant Human CCND1 protein, DDK-tagged |
| Product Overview: | Recombinant Human CCND1 fused with DDK tag at C-terminal was expressed in Insect cells. |
| Description: | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 34 kDa |
| Purity: | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Species: | Human |
| Formulation: | 50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol. |
| Tag: | DDK |
| Expression System: | Insect Cells |
| Concentrations: | >50 ug/mL as determined by microplate BCA method |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | CCND1 cyclin D1 (PRAD1: parathyroid adenomatosis 1) [ Homo sapiens ] |
| Gene ID NCBI: | 595 |
| Official Symbol: | CCND1 |
| Synonyms: | BCL1; PRAD1; U21B31; D11S287E |
| mRNA Refseq: | NM_053056 |
| Protein Refseq: | NP_444284 |
| MIM: | 168461 |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0060 | Recombinant Human CCND1 293 Cell Lysate | Inquiry |
| EL-0120 | Recombinant Human CCNB1 Cell Lysate | Inquiry |
| EL-0197 | Recombinant Human CCDC101 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0515 | Recombinant Human Cyclin D1, GST-tagged | Inquiry |
| PE-0516 | Recombinant Human CCND1, His-tagged | Inquiry |
| Related Gene / Proteins | |||
| CCDC101 | CCL14 | CCNB1 | CCND1 |
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