Recombinant Human CCND1 protein, Flag-tagged

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Cat.No.:  PE-0526
Product Name:  Recombinant Human CCND1 protein, Flag-tagged
Product Overview:  Recombinant Human CCND1 fused with flag tag at C-terminal was expressed in Insect cells.
Description:  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Storage:  Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:  34 kDa
Purity:  > 80% as determined by SDS-PAGE and Coomassie blue staining
Species:  Human
Formulation:  50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 7 months from receipt of products under proper storage and handling conditions.
Tag:  Flag
Expression System:  Insect Cells
Concentrations:  >50 ug/mL as determined by microplate BCA method
Warning:  This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name:  CCND1 cyclin D1 (PRAD1: parathyroid adenomatosis 1) [ Homo sapiens ]
Gene ID NCBI:  893
Official Symbol:  CCND1
Synonyms:  CCND1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); BCL1, cyclin D1 (PRAD1: parathyroid adenomatosis 1) , D11S287E, PRAD1; B cell CLL/lymphoma 1; G1/S specific cyclin D1; parathyroid adenomatosis 1; U21B31; BCL-1; PRAD1; D11S287E;
mRNA Refseq:  NM_053056
Protein Refseq:  NP_444284
MIM:  168461
UniProt ID:  P24385
Chromosome Location:  11q13

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