| Cat.No.: | PE-0475 |
| Product Name: | Recombinant Human HDAC9, His-tagged |
| Product Overview: | Recombinant fragment corresponding to amino acids 604-1066 of Human HDAC 9 with C-terminal His tag expressed in a Baculovirus infected Sf9 cell expression system, 50.7 kDa. |
| Description: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. |
| Tissue Specificity: | Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level). |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Purity: | >95% by SDS-PAGE |
| Species: | Human |
| Tag: | His |
| Sequence Similarities: | Belongs to the histone deacetylase family. HD type 2 subfamily. |
| Activity: | Specific Activity: >1000 U/ug. One U =1pmol/min.Assay condition: 25 mM Tris/Cl, pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 20 uM BPS HDAC substrate, and 0.2 ng/ul HDAC9. Incubation condition: 30 min at 37oC. |
| Expression System: | Sf9 Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC9 histone deacetylase 9 [ Homo sapiens ] |
| Gene ID NCBI: | 9734 |
| Official Symbol: | HDAC9 |
| Synonyms: | HDAC9; histone deacetylase 9; HD7; HDAC; HDAC7B; KIAA0744; MITR; |
| mRNA Refseq: | NM_001204144 |
| Protein Refseq: | NP_001191073 |
| MIM: | 606543 |
| UniProt ID: | Q9UKV0 |
| Chromosome Location: | 7p21.1 |
| Function: | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; NOT histone deacetylase activity; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
