| Cat.No.: | PE-0413 |
| Product Name: | Recombinant Human MECP2 protein, His & T7-tagged |
| Product Overview: | Recombinant Human MECP2 aa. (Met1~Lys177 (Accession # P51608)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
| Description: | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Applications: | SDS-PAGE; WB; ELISA; IP. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Freeze-dried powder |
| Molecular Weight: | 30kDa as determined by SDS-PAGE reducing conditions. |
| Purity: | >90% |
| Species: | Human |
| Tag: | His & T7 |
| Endotoxin: | <1.0EU per 1ug (determined by the LAL method) |
| Reconstitution: | Reconstitute in sterile ddH2O. |
| Expression System: | E. coli |
| Isoelectric Point: | The isoelectric point is 9.6. |
| Protein Length: | Met1~Lys177 (Accession # P51608) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | MECP2 methyl-CpG binding protein 2 [ Homo sapiens (human) ] |
| Gene ID NCBI: | 4204 |
| Official Symbol: | MECP2 |
| Synonyms: | MECP2; methyl-CpG binding protein 2; RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13; methyl-CpG-binding protein 2; meCp-2 protein; testis tissue sperm-binding protein Li 41a |
| mRNA Refseq: | NM_001110792.1 |
| Protein Refseq: | NP_001104262.1 |
| UniProt ID: | P51608 |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0043 | Recombinant Human MECP2 293 Cell Lysate | Inquiry |
| EL-0111 | Recombinant Human MEF2B Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0067 | MeCP2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0109 | Human MECP2 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0110 | Human MEN1 Knockout Cell Line 1bp insertion | Inquiry |
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