| Cat.No.: | PE-0405 |
| Product Name: | Recombinant Human MECP2, GST-tagged |
| Product Overview: | Recombinant Human MECP2 (78-162 a.a.) fused with GST-tag at N-terminal, was expressed in E. coli expression system.. |
| Description: | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. |
| Applications: | Useful for the study of DNA binding, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 36 kDa |
| Species: | Human |
| Formulation: | 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.2 mM KCl, 18 mM glutathione, 10% glycerol and 3 mM DTT. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | MECP2 methyl CpG binding protein 2 (Rett syndrome) [ Homo sapiens ] |
| Gene ID NCBI: | 4204 |
| Synonyms: | MECP2; methyl CpG binding protein 2 (Rett syndrome); mental retardation, X linked 16 , mental retardation, X linked 79; MRX16; MRX79; RTT; methyl-CpG-binding protein 2 |
| mRNA Refseq: | NM_004992 |
| Protein Refseq: | NP_004983 |
| MIM: | 300005 |
| UniProt ID: | P51608 |
| Chromosome Location: | Xq28 |
| Function: | DNA binding; double-stranded methylated DNA binding; protein N-terminus binding; protein binding; protein domain specific binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0043 | Recombinant Human MECP2 293 Cell Lysate | Inquiry |
| EL-0111 | Recombinant Human MEF2B Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0067 | MeCP2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0109 | Human MECP2 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0110 | Human MEN1 Knockout Cell Line 1bp insertion | Inquiry |
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