| Cat.No.: | PE-0384 |
| Product Name: | Recombinant Mouse Crebbp, His-tagged |
| Product Overview: | Mouse CREB-binding protein fused at the C-terminus to a His-tag. |
| Description: | CREB-binding protein acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | ≥95% (SDS-PAGE) |
| Species: | Mouse |
| Formulation: | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol. |
| Tag: | His |
| Activity: | ~50-100ng are required for standard HAT assay. |
| Expression System: | Sf21 Insect Cells |
| Concentrations: | Lot dependent (0.2-0.5mg/ml) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | Crebbp CREB binding protein [ Mus musculus ] |
| Gene ID NCBI: | 12914 |
| Synonyms: | CREBBP; CREB binding protein; CREB-binding protein; CBP; KAT3A; AW558298; CBP/p300; p300/CBP; |
| mRNA Refseq: | NM_001025432 |
| Protein Refseq: | NP_001020603 |
| Function: | DNA binding; MyoD binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II transcription factor binding; RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription; SMAD binding; acetyltransferase activity; acetyltransferase activity; activating transcription factor binding; chromatin binding; core promoter proximal region sequence-specific DNA binding; histone acetyltransferase activity; histone acetyltransferase activity; metal ion binding; p53 binding; peroxisome proliferator activated receptor binding; protein binding; contributes_to sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription coactivator activity; transcription cofactor activity; transcription factor binding; transcription factor binding; transferase activity; zinc ion binding; |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0055 | Human CREBBP Knockout Cell Line 1bp insertion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0094 | C646 | Inquiry |
| BSM-0124 | EML-425 | Inquiry |
| BSM-0150 | I-CBP112 (Hydrochloride) | Inquiry |
| ◆ Research Kits | ||
| EKIT-0122 | CBP bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| CREB | CREB3 | crebbp | CRISP1 |
| CRISP3 | CRP | ||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
