| Cat.No.: | PE-0383 |
| Product Name: | Recombinant Human CREBBP, GST-tagged |
| Product Overview: | Recombinant human KAT3A (CREBBP) (1319-1710) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | KAT3A has intrinsic histone acetyltransferase activity that acts as a scaffold to stabilize additional protein interactions with the transcription complex and acetylates both histone and non-histone proteins. KAT3A (CREBBP) expressed as a nuclear protein that binds to cAMP-response element binding protein (CREB) and involved in the transcriptional coactivation of many different transcription factors. KAT3A plays a main role in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. KAT3A also plays a critical role in the transmission of inductive signals from cell surface receptors to the transcriptional apparatus. |
| Applications: | Acetyltransferase Assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | ~72 kDa |
| Purity: | >90% by densitometry |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Tag: | GST |
| Activity: | The specific activity of KAT3A (CREBBP) was determined to be 32 nmol /min/mg |
| Expression System: | Sf9 Insect Cells |
| Concentrations: | 0.1 μg/μl |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | CREBBP CREB binding protein [ Homo sapiens ] |
| Gene ID NCBI: | 1387 |
| Synonyms: | CREBBP; CREB binding protein; RSTS, Rubinstein Taybi syndrome; CREB-binding protein; CBP; KAT3A; RTS; RSTS; |
| mRNA Refseq: | NM_001079846 |
| Protein Refseq: | NP_001073315 |
| MIM: | 600140 |
| UniProt ID: | Q92793 |
| Chromosome Location: | 16p13.3 |
| Function: | DNA binding; MyoD binding; RNA polymerase II activating transcription factor binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II transcription coactivator activity; RNA polymerase II transcription factor binding; RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription; SMAD binding; acetyltransferase activity; chromatin binding; core promoter proximal region sequence-specific DNA binding; histone acetyltransferase activity; histone acetyltransferase activity; metal ion binding; p53 binding; peroxisome proliferator activated receptor binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription coactivator activity; contributes_to transcription coactivator activity; transcription coactivator activity; transcription coactivator activity; transcription factor binding; transferase activity; zinc ion binding; |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0055 | Human CREBBP Knockout Cell Line 1bp insertion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0094 | C646 | Inquiry |
| BSM-0124 | EML-425 | Inquiry |
| BSM-0150 | I-CBP112 (Hydrochloride) | Inquiry |
| ◆ Research Kits | ||
| EKIT-0122 | CBP bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| CREB | CREB3 | crebbp | CRISP1 |
| CRISP3 | CRP | ||
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