| Cat.No.: | PE-0358 |
| Product Name: | Recombinant Human BRD9, GST-tagged |
| Product Overview: | Recombinant Human BRD9 (21-137 aa) was expressed in E. coli. |
| Description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. Human BRD9 contains a single bromodomain and has five isoforms that are produced by alternative splicing. This product contains the bromodomain region of BRD9.This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 40.7 kDa (21-137 aa + GST Tag) |
| Purity: | ≥95% by SDS-PAGE |
| Species: | Human |
| Formulation: | 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol. |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | 21-137 aa |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | BRD9 bromodomain containing 9 [ Homo sapiens (human) ] |
| Gene ID NCBI: | 65980 |
| Synonyms: | BRD9; bromodomain containing 9; PRO9856; LAVS3040; bromodomain-containing protein 9; sarcoma antigen NY-SAR-29; rhabdomyosarcoma antigen MU-RMS-40.8 |
| mRNA Refseq: | NM_023924 |
| Protein Refseq: | NP_076413 |
| UniProt ID: | Q9H8M2 |
| Chromosome Location: | 5p15.33 |
| Function: | histone acetyl-lysine binding; nucleic acid binding |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0006 | Bromodomain Ligand 4 | Inquiry |
| Related Gene / Proteins | |||
| BRCA1 | BRCA2 | BRCC3 | BRD |
| brd1 | brd2 | brd3 | brd4 |
| BRD7 | BRD8 | brd9 | brdt |
| BRL | BRM | BRMS1 | BRPF1 |
| BRPF2 | brpf3 | BRWD1 | BRWD3 |
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