| Cat.No.: | PE-0314 |
| Product Name: | Recombinant Human BRD1, GST-tagged |
| Product Overview: | Recombinant Human BRD1 (556-680 aa) was expressed in E. coli. |
| Description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. BRD1 is a bromodomain containing protein that has been identified as a susceptibility gene in neurological disorders, such as schizophrenia and bipolar affective disorder. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 41.1 kDa (556-680 aa + NT GST Tag) |
| Purity: | ≥95% by SDS-PAGE |
| Species: | Human |
| Formulation: | 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol. |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | 556-680 aa |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | BRD1 bromodomain containing 1 [ Homo sapiens (human) ] |
| Gene ID NCBI: | 23774 |
| Synonyms: | BRD1; bromodomain containing 1; BRL; BRPF1; BRPF2; bromodomain-containing protein 1; BR140-like protein; bromodomain and PHD finger-containing protein 2 |
| mRNA Refseq: | NM_014577 |
| Protein Refseq: | NP_055392 |
| MIM: | 604589 |
| UniProt ID: | O95696 |
| Chromosome Location: | 22q13.33 |
| Function: | histone binding; zinc ion binding |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0006 | Bromodomain Ligand 4 | Inquiry |
| Related Gene / Proteins | |||
| BRCA1 | BRCA2 | BRCC3 | BRD |
| brd1 | brd2 | brd3 | brd4 |
| BRD7 | BRD8 | brd9 | brdt |
| BRL | BRM | BRMS1 | BRPF1 |
| BRPF2 | brpf3 | BRWD1 | BRWD3 |
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