| Cat.No.: | PE-0266 |
| Product Name: | Recombinant Human DNMT3A, GST-tagged |
| Product Overview: | Recombinant Human DNMT3a, (a-a 2-913), with N-terminal GST tag expressed in baculovirus . MW= 128 kDa. |
| Description: | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Applications: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | >50%. |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol. |
| Tag: | GST |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha [ Homo sapiens ] |
| Gene ID NCBI: | 1788 |
| Synonyms: | DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNMT3A2; M.HsaIIIA; EC 2.1.1.37; DNA MTase HsaIIIA; DNA methyltransferase HsaIIIA; DNA cytosine methyltransferase 3A2; DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; DNA MTase HsaIIIA |
| mRNA Refseq: | NM_022552 |
| Protein Refseq: | NP_072046 |
| MIM: | 602769 |
| UniProt ID: | Q9Y6K1 |
| Chromosome Location: | 2p23 |
| Function: | DNA (cytosine-5-)-methyltransferase activity; DNA binding; metal ion binding; chromatin binding; transferase activity; zinc ion binding |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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