| Cat.No.: | PE-0262 |
| Product Name: | Recombinant Mouse Dnmt1 |
| Product Overview: | mouse Dnmt1 deleting the N-terminal 290 amino acid residues, was expressed using a baculovirus expression system |
| Description: | DNA methylation is significant for epigenetic regulation of gene expression, X chromosome inactivation, genomic imprinting, and development. Abberant methylation patterns are associated with certain human tumors and developmental abnormalities. In vertebrates, there are two types of DNA methyltransferase activities; de novo and maintenance types. Two DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the creation of methylation patterns at an early stage of embryogenesis (de novo-type), while Dnmt1 is responsible for the maintenance of methylation patterns during replication. Dnmt1 favors to methylate the hemimethylated DNA and preferentially methylates one strand of the double-stranded DNA during its processive methylation. |
| Applications: | 1) In vitro metylation of cytosine residues in hemimethylated DNA at 5"…CG…3".2) Antigen for anti-mammalian Dnmt1 antibodies |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% protein determined by SDS-PAGE (CBB staining) |
| Species: | Mouse |
| Formulation: | 0.5mg protein/ml in 0.2M NaCl, 10mM HEPES (pH 7.4), 50% glycerol |
| Activity: | 17 units/ul |
| Expression System: | Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | Dnmt1 DNA methyltransferase (cytosine-5) 1 [ Mus musculus ] |
| Gene ID NCBI: | 13433 |
| Synonyms: | DNMT1; DNA methyltransferase (cytosine-5) 1; DNA (cytosine-5)-methyltransferase 1; DNA MTase MmuI; DNA methyltransferase MmuI; Dnmt; MCMT; Met1; Cxxc9; MTase; Met-1; Dnmt1o; m.MmuI; MommeD2; |
| mRNA Refseq: | NM_001199431 |
| Protein Refseq: | NP_001186360 |
| Function: | DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; DNA binding; DNA binding; DNA-methyltransferase activity; catalytic activity; double-stranded DNA binding; histone deacetylase binding; metal ion binding; methyl-CpG binding; methyltransferase activity; protein binding; protein domain specific binding; transcription factor binding; transferase activity; unmethylated CpG binding; zinc ion binding; |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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