| Cat.No.: | PE-0219 |
| Product Name: | Recombinant Human EZH2, His-GST-tagged |
| Product Overview: | Recombinant Human EZH2(amino acids 2-end), fused with N-terminal His-GST tag, was expressed in a Sf9 baculovirus expression system. |
| Description: | This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. |
| Applications: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 114 kDa |
| Purity: | Purity>65% |
| Species: | Human |
| Formulation: | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 16 mM glutathione and 20% Glycerol. |
| Tag: | His-GST |
| Expression System: | Sf9 Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Homo sapiens (human) ] |
| Gene ID NCBI: | 2146 |
| Synonyms: | EZH2; enhancer of zeste homolog 2 (Drosophila); enhancer of zeste (Drosophila) homolog 2; histone-lysine N-methyltransferase EZH2; ENX 1; EZH1; KMT6; KMT6A |
| mRNA Refseq: | NM_004456 |
| Protein Refseq: | NP_004447 |
| MIM: | 601573 |
| Chromosome Location: | 7q35-q36 |
| Function: | RNA binding; histone methyltransferase activity; histone methyltransferase activity (H3-K27 specific) |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0006 | GSK343 | Inquiry |
| BSM-0059 | 3-Deazaneplanocin A | Inquiry |
| BSM-0060 | 3-Deazaneplanocin A hydrochloride | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0024 | Recombinant Human EZH1 293 Cell Lysate | Inquiry |
| EL-0025 | Recombinant Human EZH2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| ezh1 | EZH2 | ||
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