| Cat.No.: | PE-0205 |
| Product Name: | Recombinant Human SIRT7, Flag-tagged |
| Product Overview: | Recombinant Human SIRT7, fused with C-terminal Flag tag, was expressed in an E. coli cell expression system. |
| Description: | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. |
| Applications: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 46 kDa |
| Purity: | >60% |
| Species: | Human |
| Formulation: | 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl and 10% glycerol. |
| Tag: | Flag |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SIRT7 sirtuin 7 [ Homo sapiens (human) ] |
| Gene ID NCBI: | 51547 |
| Synonyms: | SIRT7; SIR2L7; sirtuin 7; NAD-dependent protein deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7; sir2-related protein type 7; regulatory protein SIR2 homolog 7; NAD-dependent deacetylase sirtuin-7; silent mating type information regulation 2, S.cerevisiae, homolog 7; NP_057622.1; EC 3.5.1.- |
| mRNA Refseq: | NM_016538 |
| Protein Refseq: | NP_057622 |
| MIM: | 606212 |
| Chromosome Location: | 17q25 |
| Function: | NAD+ binding; NAD-dependent histone deacetylase activity (H3-K18 specific); chromatin binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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