| Cat.No.: | PE-0179 |
| Product Name: | Recombinant Human Sirtuin 5, His-tagged |
| Product Overview: | Recombinant full length human SIRT5 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
| Description: | SIRT5 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT5 being a member of class III. SIRT5 consists of eight exons and is found in two isoforms which encode a 310 aa and a 299 aa protein, respectively. Human SIRT5 is most predominantly expressed in heart muscle cells and in lymphoblasts. |
| Applications: | SIRT Assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 39 kDa |
| Purity: | > 80 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol. |
| Tag: | His |
| Activity: | 20 RLU/min/mg |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Full-length |
| Concentrations: | 0.1 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SIRT5 sirtuin 5 [ Homo sapiens ] |
| Gene ID NCBI: | 23408 |
| Official Symbol: | SIRT5 |
| Synonyms: | SIRT5; sirtuin 5; SIR2L5; FLJ36950; NAD-dependent deacetylase sirtuin-5; sir2-like 5; sirtuin type 5; OTTHUMP00000016054; OTTHUMP00000016055; SIR2-like protein 5; silent mating type information regulation 2, S.cerevisiae, homolog 5; EC 3.5.1.-; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 5 |
| mRNA Refseq: | NM_012241 |
| Protein Refseq: | NP_036373 |
| MIM: | 604483 |
| UniProt ID: | Q9NXA8 |
| Chromosome Location: | 6p23 |
| Function: | NAD binding; NAD+ ADP-ribosyltransferase activity; hydrolase activity; hydrolase activity; metal ion binding; zinc ion binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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