| Cat.No.: | PE-0178 |
| Product Name: | Recombinant Human SIRT5 |
| Description: | Sirtuins are pylogenetically conserved from bacteria to humans and regulate cell functions beyond silencing. The proteins show a relevance to cancer, obesity, muscle differentiation, inflammation and neuro-degeneration. In addition, Sirtuin activity may extend the lifespan of several organisms. Human Sirtuin 5 (Sirt5) is a mitochondrial member of Class III of the protein deacetylases family (historically called histone deacetylases family). Class III deacetylases utilize NAD+ as cosubstrate and act either as deacetylases or as ADP-ribosyltransferases. MW=29.9kDa (275 amino acids). |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | >95% by SDS-PAGE. |
| Species: | Human |
| Formulation: | Purified recombinant protein in 20mM Tris-HCl pH7.8, 150mM NaCl and 2mM DTT. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SIRT5 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) [ Homo sapiens ] |
| Gene ID NCBI: | 23408 |
| Synonyms: | SIRT5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); SIR2L5; FLJ36950; sirtuin 5; sir2-like 5; sirtuin type 5; silent mating type information regulation 2, S.cerevisiae, homolog 5; EC 3.5.1.-; OTTHUMP00000016054; OTTHUMP00000016055; SIR2-like protein 5; sirtuin (silent mating type information regulation; S.cerevisiae, homolog) 5 |
| mRNA Refseq: | NM_012241 |
| Protein Refseq: | NP_036373 |
| MIM: | 604483 |
| UniProt ID: | Q9NXA8 |
| Chromosome Location: | 6p23 |
| Function: | NAD binding; NAD+ ADP-ribosyltransferase activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; zinc ion binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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