| Cat.No.: | PE-0170 |
| Product Name: | Recombinant Human Sirtuin 4, GST-tagged |
| Product Overview: | Full-length recombinant human SIRT4 was expressed in E. coli cells using an N-terminal GST tag. |
| Description: | SIRT4 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT4 being a member of class IV. SIRT4 lacks deacetylase activity but has ADP-ribosyltransferase activity. Immunoprecipitation analysis shows that SIRT4 interacts with the mitochondrial enzyme glutamate dehydrogenase, and functional analysis show that SIRT4 ADP-ribosylates and inhibits GDH. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 62 kDa |
| Purity: | > 70 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | Full-length |
| Concentrations: | 0.2 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SIRT4 sirtuin 4 [ Homo sapiens ] |
| Gene ID NCBI: | 23409 |
| Official Symbol: | SIRT4 |
| Synonyms: | SIRT4; sirtuin 4; SIR2L4; MGC57437; MGC130046; MGC130047; NAD-dependent ADP-ribosyltransferase sirtuin-4; sir2-like 4; sirtuin type 4; OTTHUMP00000239957; SIR2-like protein 4; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4 |
| mRNA Refseq: | NM_012240 |
| Protein Refseq: | NP_036372 |
| MIM: | 604482 |
| UniProt ID: | Q9Y6E7 |
| Chromosome Location: | 12q24.31 |
| Function: | NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; hydrolase activity; metal ion binding; protein binding; transferase activity; zinc ion binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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