| Cat.No.: | PE-0169 |
| Product Name: | Recombinant Human SIRT4, GST-tagged |
| Product Overview: | Recombinant Human SIRT4 (amino acids 25-314) was expressed in an E.coli expression system with N-terminal GST tag. MW=59 kDa. |
| Description: | Sirtuin 4, also known as SIRT4 is a protein which in humans is encoded by the SIRT4 gene. This gene encodes a member of the sirtuin family of proteins which are homologs of the Sir2 gene in budding yeast. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been fully determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. |
| Applications: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | > 90%. |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SIRT4 sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) [ Homo sapiens ] |
| Gene ID NCBI: | 23409 |
| Synonyms: | sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); SIR2L4; MGC57437; MGC130046; MGC130047; SIRT4; sirtuin 4; sir2-like 4; sirtuin type 4; EC 3.5.1.-; SIR2-like protein 4; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 4 |
| mRNA Refseq: | NM_012240 |
| Protein Refseq: | NP_036372 |
| MIM: | 604482 |
| UniProt ID: | Q9Y6E7 |
| Chromosome Location: | 12q |
| Function: | NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; protein binding; transferase activity; zinc ion binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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