| Cat.No.: | PE-0139 |
| Product Name: | Recombinant Human Sirtuin 2, His-tagged |
| Product Overview: | Recombinant full length human SIRT2 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
| Description: | SIRT2 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT2 being a member of class I. Inhibition of SIRT2 can lead to neuroprotection in cellular and invertebrate models of Huntington" s disease. Huntington"s disease is characterized by increased sterol synthesis in neuronal cells and this process is reversed by SIRT2 inhibition. |
| Applications: | SIRT Assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 42 kDa |
| Purity: | > 70 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol. |
| Tag: | His |
| Activity: | 8000 RLU/min/mg |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Full-length |
| Concentrations: | 0.1 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SIRT2 sirtuin 2 [ Homo sapiens ] |
| Gene ID NCBI: | 22933 |
| Official Symbol: | SIRT2 |
| Synonyms: | SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; FLJ35621; FLJ37491; NAD-dependent deacetylase sirtuin-2; sirtuin type 2; OTTHUMP00000197460; OTTHUMP00000197461; OTTHUMP00000197465; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; EC 3.5.1.-; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 2 |
| mRNA Refseq: | NM_012237 |
| Protein Refseq: | NP_036369 |
| MIM: | 604480 |
| UniProt ID: | Q8IXJ6 |
| Chromosome Location: | 19q13 |
| Function: | NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; hydrolase activity; metal ion binding; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding; protein binding; protein deacetylase activity |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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