| Cat.No.: | PE-0089 |
| Product Name: | Recombinant Human HDAC7 |
| Product Overview: | Recombinant fragment of Human HDAC7 expressed in a Baculovirus infected Sf9 cell expression system with N-terminal proprietary tag, 80kDa. |
| Description: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 80.000kDa inclusive of tags |
| Purity: | >90% by SDS-PAGE |
| Species: | Human |
| Sequence Similarities: | Belongs to the histone deacetylase family. HD type 2 subfamily. |
| Activity: | The Specific activity of HDAC7-29191TH was determined to be 80 RLU/min/ng. |
| Expression System: | Baculovirus |
| Protein Length: | 452 amino acids |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC7 histone deacetylase 7 [ Homo sapiens ] |
| Gene ID NCBI: | 51564 |
| Official Symbol: | HDAC7 |
| Synonyms: | HDAC7; histone deacetylase 7; HDAC7A, histone deacetylase 7A; DKFZP586J0917; |
| mRNA Refseq: | NM_001098416 |
| Protein Refseq: | NP_001091886 |
| MIM: | 606542 |
| UniProt ID: | Q8WUI4 |
| Chromosome Location: | 12q13.1 |
| Function: | 14-3-3 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); activating transcription factor binding; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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