| Cat.No.: | PE-0045 |
| Product Name: | Recombinant Human HDAC3, His-tagged |
| Product Overview: | Recombinant Human HDAC3 was expressed in insect cell. |
| Description: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. |
| Applications: | Study HDAC3 kinetics and inhibitor sensitivity and also the effect of the enzyme in transcriptional regulation, cell cycle progression, and oncogenesis. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 49 kDa |
| Purity: | ~50% by SDS-PAGE. |
| Species: | Human |
| Formulation: | 103 μg/μl in 50 mM Tris, pH 8.0, 138 mM NaCl and 10% glycerol. |
| Tag: | His |
| Activity: | >1 U/µg. |
| Expression System: | Insect Cells |
| Protein Length: | 428 amino acids |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC3 histone deacetylase 3 [ Homo sapiens (human) ] |
| Gene ID NCBI: | 8841 |
| Synonyms: | HDAC3; histone deacetylase 3; HD3; RPD3; RPD3-2; histone deacetylase 3; SMAP45; EC 3.5.1.98 |
| mRNA Refseq: | NM_003883 |
| Protein Refseq: | NP_003874 |
| MIM: | 605166 |
| Chromosome Location: | 5q31 |
| Function: | chromatin DNA binding; enzyme binding; histone deacetylase activity; protein binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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