| Cat.No.: | PE-0036 |
| Product Name: | Recombinant Human HDAC2 protein, His-tagged |
| Product Overview: | Recombinant Human HDAC2 fused with His tag was expressed in Insect cells. |
| Description: | HDAC2 is a member of the histone deacetylase family that performs through the construction of large multiprotein complexes and are in charge of the deacetylation of lysine residues on the N-terminal region of the core histones. HDAC2 forms transcriptional repressor complexes by relating to a diversity of proteins, like YY1- a mammalian zinc-finger transcription factor. Additionally, HDAC2 has a vital part in transcriptional regulation, cell cycle progression and developmental procedures. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 56.2 kDa, observed by reducing SDS-PAGE. |
| Purity: | > 80% by SDS-PAGE analysis. |
| Species: | Human |
| Formulation: | The HDAC2 solution contains 20 mM Tris-HCl buffer (pH 8.0), 300 mM NaCl and 20% Glycerol. Frozen solution. |
| Tag: | His |
| Amino Acid Sequence: | MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTHNLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSIRPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLAILELLKYHQR VLYIDIDIHH GDGVEEAFYT TDRVMTVSFHKYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVKGHAKCVEVVK TFNLPLLMLG GGGYTIRNVA RCWTYETAVALDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGEDPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKKGAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT KSEQLSNPGH HHHHH |
| Endotoxin: | < 1 EU/μg, determined by LAL method. |
| Activity: | > 500 pmol/min/μg |
| Expression System: | Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC2 histone deacetylase 2 [ Homo sapiens ] |
| Gene ID NCBI: | 3066 |
| Official Symbol: | HDAC2 |
| Synonyms: | HDAC2; histone deacetylase 2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3; HD2; |
| mRNA Refseq: | NM_001527 |
| Protein Refseq: | NP_001518 |
| MIM: | 605164 |
| UniProt ID: | Q92769 |
| Chromosome Location: | 6q21 |
| Function: | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); chromatin binding; enzyme binding; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; protein binding; protein deacetylase activity; sequence-specific DNA binding; transcription factor binding; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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