RNF20 Monoclonal Antibody


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Cat.No.:  EAb-3418
Product Name:  RNF20 Monoclonal Antibody
Antibody Type:  Monoclonal
Immunogen:  A synthetic peptide of human RNF20
Host:  Mouse
Isotype:  IgG
Molecular Weight:  127kDa
Purification:  Affinity purification
Appearance:  Liquid
Applications:  WB
Recommended Dilutions/Conditions:  WB: 1:200 - 1:500
Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Positive Control:  U-87MG,Jurkat,HeLa,MCF7,A-431
Species Reactivity:  Human
Storage:  4℃.
Storage Buffer:  PBS with 0.02% sodium azide, pH7.3.
Warning:  For Research Use Only! Not For Use in Humans.
Accession:  Swiss Prot Q5VTR2; Gene ID 56254
Alternative Name:  RNF20; BRE1; BRE1A; hBRE1; ring finger protein 20
Scientific Background:  The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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