| Cat.No.: | EAb-3226 |
| Product Name: | Dnmt3a (phospho S390/S393) Polyclonal Antibody |
| Product Overview: | Rabbit polyclonal to detect Dnmt3a (phospho S390/S393) |
| Antibody Type: | Polyclonal |
| Immunogen: | Synthetic peptide conjugated to KLH derived from within residues 350 - 450 of Human Dnmt3a, phosphorylated at S390 and phosphorylated at S393. |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Immunogen affinity purified |
| Appearance: | Liquid |
| Formulation: | pH: 7.40; 0.02% Sodium azide, PBS |
| Applications: | ICC/IF, WB |
| Species Reactivity: | Human |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | DNA (cytosine 5) methyltransferase 3 alpha antibody/DNA (cytosine 5) methyltransferase 3A antibody/DNA (cytosine-5)-methyltransferase 3A antibody |
| Scientific Background: | Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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