| Cat.No.: | EAb-3193 |
| Product Name: | Dnmt1 Monoclonal Antibody (60B1220.1) - Biotin |
| Product Overview: | Mouse monoclonal (60B1220.1) to detect Dnmt1 (Biotin) |
| Antibody Type: | Monoclonal |
| Clone Designation: | 60B1220.1 |
| Immunogen: | Synthetic peptide corresponding to Human Dnmt1 aa 637-650. |
| Immunogen Sequence: | EKDDREDKENAFKR |
| Host: | Mouse |
| Isotype: | IgG1 |
| Purification: | Protein G purified |
| Appearance: | Liquid |
| Formulation: | 0.05% Sodium azide, 99% PBS, 0.05% BSA |
| Applications: | WB, IHC-P, IHC-Fr |
| Species Reactivity: | Mouse, Human, Zebrafish |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P26358; NP_001370 |
| Alternative Name: | ADCADN antibody/AIM antibody/CXXC finger protein 9 antibody |
| Scientific Background: | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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