USP34 Polyclonal Antibody

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Cat.No.:  EAb-2838
Product Name:  USP34 Polyclonal Antibody
Product Overview:  Rabbit polyclonal to detect USP34
Antibody Type:  Polyclonal
Immunogen:  Synthetic peptide corresponding to a region between residue 3350 and the C-terminus (residue 3395) of Human USP34 (CAE51938.1).
Host:  Rabbit
Isotype:  IgG
Purification:  Immunogen affinity purified
Appearance:  Liquid
Formulation:  0.09% Sodium azide, Tris buffered saline, 0.1% BSA
Applications:  IHC-P
Species Reactivity:  Human
Storage:  -20°C.
Warning:  For Research Use Only! Not For Use in Humans.
Alternative Name:  Deubiquitinating enzyme 34 antibody/FLJ43910 antibody/KIAA0570 antibody
Scientific Background:  Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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