| Cat.No.: | EAb-2736 |
| Product Name: | TIP49A Polyclonal Antibody |
| Product Overview: | Rabbit polyclonal to detect TIP49A |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant fragment, corresponding to a region within amino acids 163-456 of Human TIP49A |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Immunogen affinity purified |
| Appearance: | Liquid |
| Formulation: | pH: 7.00; 0.01% Thimerosal (merthiolate), 1.21% Tris, 0.75% Glycine, 20% Glycerol |
| Applications: | WB |
| Species Reactivity: | Human |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q9Y265 |
| Alternative Name: | 49 kDa TATA box binding protein interacting protein antibody/49 kDa TATA box-binding protein-interacting protein antibody/49 kDa TBP interacting protein antibody |
| Scientific Background: | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.May be able to bind plasminogen at cell surface and enhance plasminogen activation.Essential for cell proliferation. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0014 | TIP60 Polyclonal Antibody | Inquiry |
| EAb-0015 | TIP60 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1664 | TRIM24 (TIF1), GST-tag | Inquiry |
| PE-1667 | TRIM24 (TIF1), His-tag | Inquiry |
| PE-1887 | TIP60 (human recombinant) | Inquiry |
| Related Gene / Proteins | |||
| TIAL1 | TIEG1 | TIF1 | TIGD4 |
| TIGD5 | TIP49A | TIP49B | TIP60 |
| TIS11D | |||
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