| Cat.No.: | EAb-2721 |
| Product Name: | Aurora B Polyclonal Antibody |
| Product Overview: | Rabbit polyclonal to detect Aurora B |
| Antibody Type: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to a region between residue 300 and the C-terminus (residue 344) of Human Aurora B. |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Immunogen affinity purified |
| Appearance: | Liquid |
| Formulation: | 0.09% Sodium azide, 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS |
| Applications: | WB, IP, ICC/IF, ICC |
| Species Reactivity: | Human |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q96GD4 |
| Alternative Name: | AURKB; AIK2; AIM-1; AIM1; ARK2; AurB; IPL1; PPP1R48; STK12; STK5; aurkb-sv1; aurkb-sv2; aurora kinase B |
| Scientific Background: | May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP. |
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