| Cat.No.: | EAb-2562 |
| Product Name: | SETDB1 Monoclonal Antibody (5H6A12) |
| Product Overview: | Mouse monoclonal (5H6A12) to detect KMT1E/SETDB1 |
| Antibody Type: | Monoclonal |
| Clone Designation: | 5H6A12 |
| Immunogen: | Purified recombinant fragment of human SETDB1 expressed in E. Coli. |
| Host: | Mouse |
| Isotype: | IgG1 |
| Purification: | Protein G purified |
| Appearance: | Liquid |
| Formulation: | 0.05% Sodium azide, PBS |
| Applications: | Flow Cyt, WB, ICC/IF, ELISA |
| Species Reactivity: | Mouse, Human, Monkey |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | AU022152 antibody/EC 2.1.1.43 antibody/ERG-associated protein with SET domain antibody |
| Scientific Background: | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| SENP3 | SENP8 | SET | SET1 |
| SET2 | SET7 | SET8 | SET9 |
| SETBP1 | SETD1A | SETD1B | SETD2 |
| SETD3 | SETD5 | SETD6 | SETD7 |
| SETD8 | SETD9 | SetDB1 | SETDB2 More > |
| SETMAR | |||
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