| Cat.No.: | EAb-2316 |
| Product Name: | SUV39H1 Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This SUV39H1 antibody was raised against a recombinant protein corresponding to amino acids 1-126 of mouse SUV39H1. |
| Host: | Mouse |
| Isotype: | IgG1 |
| Molecular Weight: | 50 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | ChIP; IP; WB; ICC |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | SUV39H1 is one of two homologues of the Drosophila Suppressor-of-variegation 3(9) protein (aka Su(var)3-9). SUV39H1 is a SET domain-containing histone methyltransferase specific for lysine 9 of histone H3. Lysine 9 methylation of histone H3 is found at regions of the genome that are transcriptionally silenced, such as centromeres, repetitive elements and inactive genes. H3 lysine 9 methylation is a hallmark of heterochromatin, regions of the genome that are in a tightly compacted state and relatively devoid of gene expression. HP1 proteins recognize and bind lysine 9 methylation and this contributes to maintaining heterochromatin in its compact and inactive state. SUV39H1 also contains a chromodomain, which may bind to lysine 9 methylation and contribute to the regional spreading of lysine 9 methylation and the establishment of heterochromatin over broader domains of the genome. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0020 | Suz12 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0100 | Chaetocin | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0103 | Recombinant Human SUZ12 293 Cell Lysate | Inquiry |
| EL-0132 | Recombinant Human SUV39H1 293 Cell Lysate | Inquiry |
| EL-0137 | Recombinant Human SUV420H1 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| SUDS3 | SUMO | SUMO1 | SUMO2 |
| SUMO3 | SUN1 | Surf6 | suv39h1 |
| SUV39H2 | SUV3L1 | SUV420H1 | SUV420H2 |
| SUZ12 | |||
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