Suz12 Monoclonal Antibody


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Cat.No.:  EAb-2315
Product Name:  Suz12 Monoclonal Antibody
Antibody Type:  Monoclonal
Immunogen:  This Suz12 antibody was raised against a recombinant protein corresponding to full-length human Suz12.
Host:  Mouse
Isotype:  IgG2b
Molecular Weight:  95 kDa
Purification:  Protein G Chromatography
Appearance:  Liquid
Formulation:  Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide.
Applications:  ChIP: 2.5 - 10 µg per ChIP; IP; IHC ^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Species Reactivity:  Human
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Scientific Background:  Suz12 (Suppressor-of-Zeste 12 protein, also designated as ChET9, JJAZ1 protein) is a component of the Polycomb group complexes 2, 3 and 4 (PRC2, PRC3 and PRC4), which also contain the histone methyltransferase EZH2, EED (Embryonic Ectoderm Development protein) protein and the histone-binding proteins RbAP46 and RbAP48. PRC2 is responsible for di- and trimethylation of histone 3 at lysine 27 (Histone H3K27me2 and Histone H3K27me3), which leads to transcriptional repression of the target genes. Suz12 is a nuclear protein belonging to the VEFS family. Suz12 contains a zinc-finger binding motif and a VEFS box, which is required for the interaction between Suz12 and EZH2.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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