| Cat.No.: | EAb-2166 |
| Product Name: | MLL / HRX Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This MLL / HRX antibody was raised against a recombinant protein corresponding to amino acids 2829-2883 of human MLL. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 180 kDa |
| Purification: | Protein A Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | ChIP: 5 - 10 µg per ChIP; ChIP-Seq: 5 - 10 µg each; ICC/IF: 0.5 µg/ml dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | MLL (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)), also known as Histone-lysine N-methyltransferase HRX, is a histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1 /MLL complex, a multiprotein complex that mediates both methylation of ‘Lys-4’ of histone H3 (H3K4me) complex and acetylation of ‘Lys-16’ of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0170 | MI-3 | Inquiry |
| BSM-0187 | OICR-9429 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0172 | Human KMT2C / MLL3 peptide | Inquiry |
| ◆ Research Kits | ||
| EKIT-0285 | MLL1 Complex Chemiluminescent Assay Kit | Inquiry |
| EKIT-0286 | MLL1 SAM-Screener Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| HRX | MLH1 | MLL | mll1 |
| MLL2 | MLL3 | MLL4 | MLL5 |
| MLLT1 | MLLT3 | ||
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