PARP-2 Polyclonal Antibody

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Cat.No.:  EAb-2152
Product Name:  PARP-2 Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  This PARP-2 antibody was raised against a recombinant protein corresponding to the C-terminal region of human PARP-2.
Host:  Rabbit
Isotype:  IgG
Molecular Weight:  66 kDa
Purification:  Affinity Purified
Appearance:  Liquid
Formulation:  Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide.
Applications:  ChIP: 2 - 10 µl per ChIP; IP: 2 - 10 µl per IP; WB: 1:500 dilution; IF^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Species Reactivity:  Human
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Scientific Background:  PARP-2 encodes a chromatin-associated enzyme, a poly-ADP ribosyl transferase, which modifies various nuclear proteins by poly-ADP ribosylation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation and tumor transformation. It also plays a role in the regulation of the molecular events involved in the recovery of cells from DNA damage. PARP-2 is cleaved by caspase enzymes during the process of apoptosis.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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