| Cat.No.: | EAb-2145 |
| Product Name: | ACTL6B Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against a peptide within the N-terminal region of human ACTL6B. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 50 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:250 - 1:500 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | ACTL6B (Actin-Like 6B) belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity). |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0035 | Arecoline hydrobromide | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0045 | Recombinant Human ACTL6A 293 Cell Lysate | Inquiry |
| EL-0046 | Recombinant Human ACTL6A 293 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0193 | Human ACRBP Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-0201 | BAF53B Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| ACAT1 | ACRBP | ACTL6 | ACTR8 |
USA
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