| Cat.No.: | EAb-2113 |
| Product Name: | DOT1L Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This DOT1L antibody was raised against a peptide derived from the C-terminal region of human DOT1L. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 200 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:1,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Swiss Prot Q8TEK3; NP_115871.1; Gene ID 84444 |
| Alternative Name: | DOT1L; DOT1; KMT4; DOT1 like histone lysine methyltransferase |
| Scientific Background: | DOT1L (Disruptor of Telomeric silencing 1-like, also known as KMT4) is the mammalian homologue of the yeast Dot1 protein and the Drosophila Grappa protein. DOTL1 is the enzyme responsible for lysine 79 methylation of histone H3. DOT1L can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia, thus leading to aberrant methylation of lysine 79 at MLL target genes. In contrast to most other histone lysine methyltransferases, DOT1L does not contain a SET domain. Biochemical studies suggest that recombinant DOT1L is active on recombinant nucleosomes. |
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