| Cat.No.: | EAb-2101 |
| Product Name: | Lamin A/C Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This Lamin A/C antibody was raised against a recombinant protein corresponding to amino acids 430-545 of human Lamin A. |
| Host: | Mouse |
| Isotype: | IgG |
| Molecular Weight: | 75 kDa |
| Purification: | Culture Supernatant |
| Appearance: | Liquid |
| Formulation: | Cell culture supernatant containing mouse IgG, 30% glycerol, 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:4000 dilution; ICC/IF: 1:500 - 1:2000 dilutio; ChIP-Seq; IP^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Hamster, Human, Monkey, Mouse, Rat |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamins A and Lamins C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization results in disruption of DNA replication, transcription and RNA processing. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0180 | Human LASP1 Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-1284 | LAS1L Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-1286 | LAS1L Polyclonal Antibody, FITC Conjugated | Inquiry |
| EAb-1288 | LAS1L Polyclonal Antibody, Biotin Conjugated | Inquiry |
| EAb-1295 | LAS1L Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Lamin A | Lamin B1 | LARP1 | LARP7 |
| LAS1L | LASP1 | ||
USA
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