| Cat.No.: | EAb-2100 |
| Product Name: | Lamin A/C R453W Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This Lamin A/C R453W antibody was raised against a peptide consisting of amino acids 449-457 of human Lamin A/C containing the R453W substitution. |
| Host: | Mouse |
| Isotype: | IgG1k |
| Molecular Weight: | 65 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | IP; ICC/IF; WB |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamin A and Lamin C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization (laminopathy) results in disruption of DNA replication, transcription and RNA processing. The R453W mutation is one of the most common causes of autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD). |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0180 | Human LASP1 Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-1284 | LAS1L Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-1286 | LAS1L Polyclonal Antibody, FITC Conjugated | Inquiry |
| EAb-1288 | LAS1L Polyclonal Antibody, Biotin Conjugated | Inquiry |
| EAb-1295 | LAS1L Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Lamin A | Lamin B1 | LARP1 | LARP7 |
| LAS1L | LASP1 | ||
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