| Cat.No.: | EAb-2099 |
| Product Name: | Lamin A/C R482W Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This Lamin A/C R482W antibody was raised against a recombinant protein corresponding to amino acids 430-545 of human Lamin A/C containing the R482W substitution. |
| Host: | Mouse |
| Isotype: | IgG1 |
| Molecular Weight: | 65 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | IP; ICC/IF; WB |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamins A and Lamins C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization (laminopathy) results in disruption of DNA replication, transcription and RNA processing. The R482W mutation is involved in Dunnigan-type familial partial lipodystrophy (FPLD), a rare form of insulin resistance. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0180 | Human LASP1 Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-1284 | LAS1L Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-1286 | LAS1L Polyclonal Antibody, FITC Conjugated | Inquiry |
| EAb-1288 | LAS1L Polyclonal Antibody, Biotin Conjugated | Inquiry |
| EAb-1295 | LAS1L Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Lamin A | Lamin B1 | LARP1 | LARP7 |
| LAS1L | LASP1 | ||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
