PARP-1 N-terminal Polyclonal Antibody

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Cat.No.:  EAb-2086
Product Name:  PARP-1 N-terminal Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  This antibody was raised against a His-Tagged fusion protein corresponding to the N-terminal half of human PARP-1.
Host:  Rabbit
Isotype:  IgG
Molecular Weight:  120 kDa
Purification:  Protein A Chromatography
Appearance:  Liquid
Formulation:  Purified IgG in PBS with 30% glycerol and 0.035% sodium azide.
Applications:  ChIP-Seq: 5 µg per ChIP; IP: 10 µg per IP; WB: 0.2 - 1 µg/ml dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Species Reactivity:  Human
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Scientific Background:  PARP-1 N-terminal (ADPRT) encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation and tumor transformation. It also plays a role in the regulation of the molecular events involved in the recovery of cells from DNA damage. Cleavage of PARP-1 (ADPRT) occurs following caspase activation during apoptosis.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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